Serological effects of cypermethrin on the kidneys of rabbit (Oryctolagus cuniculus)

Abstract

Cypermethrin a commonly used synthetic pyrethroid insecticide, has become a big concern due to its harmful impact on animals. In this study, cypermethrin's (CY) serological effects were studied on the kidneys of rabbit (Oryctolagus cuniculus). Twenty rabbits were divided into four groups including three experimental (G2, G3 & G4) and one control group (G1). The three experimental groups were exposed to 500mg/kg (G2), 1000mg/kg (G3), and 1500mg/kg (G4) of dose of cypermethrin respectively, every day for fifteen days.  Blood sampling was done on the 5th, 10th, and 15th day of the experiment, the serum was separated from blood samples and two parameters including urea and creatinine were studied. The results indicated that both Urea and Creatine values were significantly different (p≤0.05) in all three experimental groups that were given cypermethrin treatment compared to the control group. In conclusion, cypermethrin is highly dangerous for mammals including rabbits when exposed to high doses.